It can be formed from trimethylglycine upon the loss of one of its methyl groups.

DMG may be prepared by the alkylation of glycine via the EschweilerClarke reaction.

In this reaction, glycine is treated with aqueous formaldehyde in formic acid that serves as both solvent and reductant.

Hydrochloric acid is added thereafter to give the hydrochloride salt.

Dmg Org Free Amino Acid

The free amino acid may have been obtained by neutralization of the acid salt, which has been performed with silver oxide.

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